HPMC Grades Viscosity Guide High-Performance K100M & 2910 Solutions

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Why HPMC Viscosity Grades Make or Break Your Formula

Our HPMC K100M viscosity maintains ±2% stability across 15-90°C. Compare that to market averages of ±8% fluctuation. See the difference?

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Real-World Wins: Case Studies That Matter

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FAQS on hpmc grades viscosity

Q: What factors determine the viscosity of HPMC grades?

A: HPMC viscosity is primarily determined by its molecular weight and degree of substitution. Higher molecular weight grades like HPMC K100M exhibit greater viscosity. Manufacturing processes also influence final viscosity specifications.

Q: How does HPMC K100M viscosity compare to other grades?

A: HPMC K100M is a high-viscosity grade, typically ranging between 80,000-120,000 mPa·s (2% aqueous solution). This exceeds mid-range grades like HPMC 2910, which usually has 40,000-60,000 mPa·s. Its thick gel formation makes it ideal for extended-release pharmaceuticals.

Q: What applications require specific HPMC viscosity grades?

A: Low-viscosity HPMC (3,000-6,000 mPa·s) suits tablet coatings, while high-viscosity grades (K100M) control drug release rates. Construction materials like tile adhesives use mid-viscosity HPMC 2910 for water retention and workability.

Q: How is HPMC 2910 viscosity measured and reported?

A: HPMC 2910 viscosity is tested via rotational viscometers (Brookfield type) at standardized concentrations (2-5% solutions). Results are expressed in mPa·s at 20°C. Manufacturers provide viscosity bands (e.g., 40,000-60,000 mPa·s) accounting for batch variations.

Q: Why does HPMC K100M show pseudoplastic behavior?

A: HPMC K100M's long polymer chains create shear-thinning properties under stress. This enables easy application during mixing while maintaining high viscosity at rest. The behavior is critical for pharmaceutical gels and ophthalmic solutions.

Q: Can temperature affect HPMC grade viscosity performance?

A: Yes, HPMC solutions exhibit inverse thermal viscosity relationships. Heating reduces viscosity due to increased molecular mobility, while cooling enhances gel strength. Formulators must account for this in temperature-sensitive applications like concrete additives.

Q: What distinguishes HPMC 2910 from K100M in pharmaceutical uses?

A: HPMC 2910 offers moderate viscosity for film coatings and matrix tablets, while K100M's ultra-high viscosity enables sustained drug release over 24+ hours. The 2910 grade also has faster hydration times compared to K100M.